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Substitute PT0/SB/8A (08-00) 
Approved for use through 10/31/2002. OMB 0651-0031 
U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE 
jperwork Reductio(A|?t of 1995, no persons are required to respond to a collection of information unless it contains a valid OMB control number 



^ti^m^ltorm 1449A/PTO 
- (Modified) 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(use as many sheets as necessary) 



Examiner 
Initials* 



Complete if Known 



Application Number 



Filing Date 



First Named Inventor 



Group Art Unit 



Examiner Name 



Attorney Docket Number 




09/847,113 



May 1, 2001 



CHUNLIN TAO 



1637 



Jeffrey Siew 



A-69306-1 



U.S. PATENT DOCUMENTS 



Cite 
No. 



A1 



A2 



A3 



A4 



A5 



U.S- Patent Oocument 
Number-Kind Code* {if known) 



4 t 81 9,658 



5,032,216 



5,200,471 



5,519,635 



5.585,646 



Publication Date 
MM-DOYYYY 



04-11-1989 



07-16-1991 



04-06-1993 



05-21-1996 



12-17-1996 



Name of Patentee or Applicant of Cited 
Oocument 



Kolodner 



Felten 



Coleman et al 



Miyake et al. 



Kossovsky et at. 



Pages. Columns. Lines, Where Relevant 
Passages or Relevant Figures Appear 



Examiner 
Initials" 



A6 



5,763,191 



06-09-1998 



Knoll et al 



A7 



5,795,953 



08-18-1998 



Kim et al. 



A8 



5.834,224 



11-10-1998 



Ruger et al. 



A9 



5,942,397 



08-24-1999 



Tarlov et al. 



A10 



6,020,047 



02-01-2000 



Everhart 



A11 



6.090,933 



07-18-2000 



Kayyem et al. 



A12 



6,096,497 



08-01-2000 



Bauer 



A13 



6,256,155 B1 



07-03-2001 



Nagaoka 



A14 



6,291,188 B1 



09-18-2001 



Meade et al. 



FOREIGN PATENT DOCUMENTS 



Cite 
No? 



B1 



B2 



B3 



B4 



B5 



B6 



Foreign Patent Document 

Country Code 2 Number 4 Kind Code 5 (// 
known) 



WO 99/57319 A1 



WO 98/57159 A1 



WO 95/34816 A1 



WO 98/20162 A3 



WO 96710178 A1 



EP 0 664 452 



Publication Oate 
MM-DO-YYYY 



11-11-1999 



12-17-1998 



12-21-1995 



05-14-1998 



04-04-1996 



07-26-1995 



Name of Patentee or Applicant of Cited 
Document 



Clinical Micro Sensors 



Clinical Micro Sensors 



Pharmacia Biosensor AB 



Clinical Micro Sensors 



Pharmacia Biosensor AB 



Boehringer Mannheim GMBH 



Pages, Columns, Lines, Where 
Relevant Passages or Relevant 



3 



Abstra 



;tOnly 




Draw lino through citation if not in conformance and not 



"EXAMINER: Initial ir reference considered, whether or not citation is in conformance with MPEP 609. 
considered. Include copy of this form with next communication to applicant. 

1 Unique citation designation number. 2 See attached Kinds of U.S. Patent Documents at www.uspto.gov or MPEP 901 .04. 3 Enter Office that issued the 
document, by the two-letter code (WIPO Standard ST.3). 4 For Japanese patent documents, (he indication of the year of the reign of the ^Perw must prec^e 
the serial number of the patent document. 5 Kind of document by the appropriate symbols as indicated on the document under WIPO Standard ST. 16 if possible. 
* Applicant is to place a check mark here if English Language Translation is attached. i nr ti xlt H t /»>c* 

Burden Hour Statement: This form is estimated to take 2.0 hours to complete. Time will vary depending upon the needs of the indwrtual case^ 
Any comments on the amount of time you are required to complete this form should be sent to the Chief InWon Oto U.S. Patent ana 
Trademark Office, Washington, DC 20231. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Assistant 
Commissioner for Patents. Washington, DC 20231. 1126452_1 




\ 




DEC 2 9 2003 S 



Substitute PTO/SB/8A (06-00) 
Approved for use through 10/31/2002. OMB 0651-0031 
U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE 



SuhJ&firte. for ion*3r449A/PTO 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(use as many sheets as necessary) 


Complete if Known 


Application Number 


09/847,113 


Filing Date 


May 1,2001 


First Named Inventor 


CHUNLIN TAO 


Group Art Unit 


1637 


Examiner Name 


Jeffrey Slew 


Sheet 2 of 3 


Attorrey Docket Number 


A-69306-1 



OTHER PRIOR ART - NON PATENT LITERATURE DOCUMENTS 



Examiner 
Initials" 


Cite 
NO, 


Include name of the author (in CAPITAL LETTERS), title of the article (when appropriate), title of the item (book, magazine, journal, serial, symposium, catalog, 


T* 




C1 


BAIN et al., "Formation of Monolayers by the Spontaneous of Thiols on Gold: Variation in the 
T entrth of the Alkvl Chain "J Am Chem Soc 1989. 11 1:7164-7175. 








C2 


B AMD AD, C. "A DNA Self- Assembled Monolayer for the Specific Attachment of Unmodified 
Double - or Sinele Stranded DNA " BiovhvsicalJournal 1998, 75:1997-2003. 




* 




C3 


CHE, G. et al., "Voltammetry of defect sites at a self-assembled monolayer on a gold surface," J. 
of Electroanalytical Chemistry, 1998, 453: 9-17. 








C4 


COLVIN, et al., Semiconductor Nanocrystals Covalently Bound to Metal burtaces with belt- 
Assembled Monolayers", J. Am. Chem. Soc, 1992, 114:5221-5230. 








C5 


Commerce Business Daily Issue, September 26, 1996, PSA#1688. 








Co 


DELAMARCHE, E. et al "Immobilization of Antibodies on a Photoactive Self-Assembled 
Monolayer on Gold", Langmuir, 1996, 12:1997-2006. 








C7 


GAFNI, et al., "Biomimetic Ion-Binding Monolayers on Gold and Their Characterization by AC- 
Impedance Spectroscopy", Chem. Eur. J., 1996, 2:759-766. 








C8 


GAO et ah, "Self-assembled conducting polymer monolayers of poly(3-octlthiophene) on gold 
electrodes," Synthetic Metals, 1995, 75:5-10. 








C9 


HSUEH et al., "Electrochemically Directed Self-Assembly on Gold," Angew. Chem. Int. Ed., 
2000, 39(7): 1227-1230. 








C10 


KUMAR et al., "Patterning Self-Assembled Monolayers: Applications in Materials Science " 
Langmuir, 1994, 10:1498-1511. 








C11 


LAIBINIS et al., "Orthogonal Self-Assembled Monolayers: Alkanethiols on Gold and Alkane 
Carboxylic Acids on Alumina," Reports, August 25, 1989, 845-847. 








C12 


LOFAS et al., "A novel hydrogel matrix on gold surfaces in surface plasmon resonance sensors 
for fast and efficient covalent immobilization of Ligands," J. Chem. Soc. Chem. Commun., 1990, 
1526-1528. 








C13 


MCGOVERN et al., "Role of Solvent on the Silanization of Glass with Octadecyltrichlorosilane," 
Langmuir, 1994, 10:3607-3614. 




i 




C14 


PARIKH et al., "An Intrinsic Relationship Between Molecular Structure in Self- Assembled n- 
Alkylsiloxane Monolayers and Deposition Temperature," J. Phys. Chem., 1994, 98:7577-7590.. 




P 


C15 


PRIME et al., "Adsorption of Proteins onto Surfaces Containing End- Attached 01igo(ethylene 
oxide): A Model System Using Self-Assembled Monolayers," J. Am. Chem. Soc, 1993, 
115:10714-10721. 






Examiner 
Signature 



* EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not 
considered. Include copy of this form with next communication to applicant. 

1 Unique citation designation number. 2 See attached Kinds of U.S. Patent Documents at www.uspto.gov or MPEP 901.04. 3 Enter Office that issued the 
document, by the two-letter code (WIPO Standard ST.3). 4 For Japanese patent documents, the indication of the year of the reign of the Emperor must precede 
the serial number of the patent document. 5 Kind of document by the appropriate symbols as indicated on the document under WIPO Standard ST. 16 if possible. 
*"Applicant is to place a check mark here if English Language Translation is attached. 

Burden Hour Statement: This form is estimated to take 2.0 hours to complete. Time will vary depending upon the needs of the individual case. 
Any comments on the amount of time you are required to complete this form should be sent to the Chief Information Officer, U.S. Patent and 
Trademark Office, Washington, DC 20231. DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Assistant 
Commissioner for Patents, Washington, DC 20231. 1 126452_1 



BEt 2 9 2803 S 



Substitute PTO/SB/8A (08-00) 
Approved for use through 10/31/2002. OMB 0651-0031 
U.S. Patent and Trademark Office: U.S. DEPARTMENT OF COMMERCE 
Under tj^Paperwork Reduction Act of 1995, no persons are required to respond to a collection of information unless it contains a valid OWB control number. 



THAni:?* Substitute for form 1 449A/PTO 

(Modified) 

INFORMATION DISCLOSURE 
STATEMENT BY APPLICANT 

(use as many sheets as necessary) 


Complete if Known 


Application Number 


09/847,113 


Filing Date 


May 1,2001 


First Named Inventor 


CHUNLIN TAO 


Group Art Unit 


1637 


Examiner Name 


Jeffrey Siew 


Sheet 


3 | of | 3 


Attorney Docket Number 


A-69306-1 



OTHER PRIOR ART - NON PATENT LITERATURE DOCUMENTS 


Examiner 
Initials* 


CMe 
No 1 


Include name of the author (in CAPITAL LETTERS), title of the article (when appropriate), litJe of the item {book, magazine, journal, serial, symposium, catalog, 

etc.). date, page(s), volume-Issue number(s), publisher, dty and/or country where published. 


T* 

t 


* 


C16 


Q (~* t-J lU'DR AT TKA f>i q1 tl A^n1f*r*n1ar 1? Rpnon it inn V»v ^f*l*T. A ^Qpmhlrf^H T\^nnnl;ivf i T*Q cif f JivitJiTifi 
1,1 v - n i r, r\. ri aa LJiVi ci <il*, iVLUiCL^uidi xvcdJgiiiinjii uy L>di -fT.Sjt-iiiui^u ivivjiivjia j' v^i o ui v^aviiaiiu 

Receptors," Science, September 2, 1994, 265: 1413-1415. 






4 


C17 


SHNEK et al., "Specific Protein Attachment to Artificial Membranes via Coordination to Lipid- 
Bound Copper (11), Langmuir> iyy4, iu.z3oz-ZJo5. 




'a 




C18 


SIGAL et al., "A Self- Assembled Monolayer for the Binding and Study of Histidine-Tagged 
Proteins by Surface Plasmon Resonance," Anal. Chem., 1996, 68(3):490-497. 




* 




C19 


SPINKE et al., "Molecular Recognition at Self-Assembled Monolayers: The Construction of 








C20 


SPINKE et al., "Molecular recognition at self-assembled monolayers: Optimization of surface 
functionalization," J. Chem. Phys. , November 1, 1993, 99(9):7012-7019. 






b 


C21 


WHITESEDES et al,, "Wet Chemical Approaches to the Characterization of Organic Surfaces: 
Self- Assembled Monol avers We trine and the Phvsical-Orcanic Chemistrv of the Solid-Liauid 
Interface," Langmuir y 1990, 6:87-96. 














































































































'EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609. Draw line through citation if not in conformance and not 
considered. Include copy of this form with next communication to applicant. 

' Unique citation designation number. 2 See attached Kinds of U.S. Patent Documents at www.uspto.gov or MPEP 901.04. 3 Enter Office that issued the 
document, by the two-letter code (WIPO Standard ST.3). A For Japanese patent documents, the indication of the year of the reign of the Emperor must precede 
the serial number of the patent document. 5 Kind of document by the appropriate symbols as indicated on the document under WIPO Standard ST. 16 if possible. 
9 Applicant is to place a check mark hero if English Language Translation is attached. 

Burden Hour Statement: This form is estimated to take 2.0 hours to complete. Time will vary depending upon the needs of the individual case. 
Any comments on the amount of time you are required to complete this form should be sent to the Chief Information Officer, U.S. Patent and 
Trademark Office, Washington, DC 20231- DO NOT SEND FEES OR COMPLETED FORMS TO THIS ADDRESS. SEND TO: Assistant 
Commissioner for Patents, Washington, DC 20231. 1 126452_1